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扁平疣是生长于青少年颜面和手背部的扁平丘疹。本文报告扁平疣的超微形态及Vitamjn B_12穴位注射治疗后的变化,在超微结构水平上探讨其治疗机理。临床上经治91例曾用其他疗法久治不愈的扁平疣患者,穴位注射Vitamin B_12,一般在一个疗程内痊愈。电镜材料取自治疗前5例,治疗中及治疗消退部位3例。治疗前扁平疣组织在电镜下与正常皮肤比较,可见上皮细胞增生异常,上皮层明显增厚,基底细胞基部大量胞浆突起插入上皮下组织,增生的棘层上皮呈不同程度超微病理改变,其中包括张力微丝表达紊乱,细丝状结构模糊不清。色素细胞明显活跃(图1)。
Flat warts are flat papules that grow on the face and back of teens. This article reports the morphological changes of flat warts and the changes after Vitamjn B_12 injection, and discusses the therapeutic mechanism at the ultrastructure level. Clinically treated 91 cases of other warts had long treatment of flat warts patients, point injection Vitamin B_12, generally cured within a course of treatment. Electron microscopy materials taken from the first 5 cases, treatment and treatment of subsided site in 3 cases. Compared with the normal skin, the flat wart tissue before treatment showed abnormal epithelial cell proliferation, thickening of the epithelial layer, massive cytoplasmic protrusion of the basal cell base into the subepithelial tissue, hyperplastic stratum spinosum epithelium with varying degrees of ultrastructural changes, Including the disturbance of the expression of tension filaments, filamentous structure blurred. Pigment cells were significantly active (Figure 1).