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目的探讨粒细胞集落刺激因子对肿瘤患者化疗后血白细胞数变化及感染危险性的影响。方法初次化疗后血白细胞降低的恶性肿瘤患者,于第2、3周期分别采用预防性或治疗性粒细胞集落刺激因子进行治疗,观察患者血白细胞数变化规律及医院感染情况。结果观察214例肿瘤化疗患者,血白细胞降低103例(下降发生率48.1%),后者医院感染率15.9%;预防性或治疗性使用粒细胞集落刺激因子均可使白细胞下降持续时间明显缩短、下降程度减轻,且前者效果明显优于后者;两种用药方法均可使Ⅱ、Ⅲ度白细胞降低患者医院感染率明显降低,而对Ⅰ、Ⅳ度降低患者作用不明显。结论肿瘤化疗患者医院感染与血白细胞降低程度密切相关;合理使用粒细胞集落刺激因子可有效减轻骨髓抑制程度,减少医院感染发生,保证化疗顺利完成。
Objective To investigate the effect of granulocyte-colony stimulating factor on the number of leukocytes and the risk of infection after chemotherapy in cancer patients. Methods Patients with malignant neoplasm whose blood leukocyte decreased after initial chemotherapy were treated with prophylactic or therapeutic granulocyte colony-stimulating factor in the second and third cycles respectively. The change of blood leukocyte count and hospital infection were observed. Results A total of 214 patients with tumor chemotherapy were observed. The number of leukopenia decreased by 103 (48.1%) and the rate of nosocomial infection was 15.9%. Prophylactic or therapeutic use of granulocyte colony-stimulating factor could significantly shorten the duration of leukopenia, Reduce the degree of reduction, and the former effect was significantly better than the latter; two kinds of medication can reduce Ⅱ, Ⅲ grade leukopenia patients hospital infection rate was significantly reduced, and Ⅰ, Ⅳ decreased in patients with no significant effect. Conclusions The nosocomial infection of patients with tumor chemotherapy is closely related to the degree of leukopenia. Proper use of granulocyte colony stimulating factor can effectively reduce the degree of myelosuppression, reduce the occurrence of nosocomial infection and ensure the successful completion of chemotherapy.