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目的探讨高压臭氧灌肠联合美沙拉嗪对炎症性肠病(IBD)治疗的临床效果。方法 76例IBD患者为研究对象,随机分为对照组与研究组,每组38例。对照组采用美沙拉嗪治疗,研究组在此基础上联合高压臭氧灌肠治疗。比较两组内镜检查疗效、临床疗效及不良反应发生情况。结果治疗2周后,研究组内镜检查总有效率94.7%高于对照组76.3%,差异具有统计学意义(P<0.05)。经过完整治疗后,研究组临床总有效率97.4%高于对照组78.9%,差异具有统计学意义(P<0.05)。研究组不良反应发生率7.9%与对照组5.3%比较差异无统计学意义(P>0.05)。结论应用高压臭氧灌肠联合美沙拉嗪治疗IBD能显著提高内镜检查疗效及临床疗效,不增加不良反应,值得推广应用。
Objective To investigate the clinical effects of high-pressure ozone enema combined with mesalazine on inflammatory bowel disease (IBD). Methods Sixty-six patients with IBD were randomly divided into control group and study group, with 38 cases in each group. The control group with mesalazine treatment, the study group on the basis of high-pressure ozone enema treatment. Efficacy, clinical efficacy and adverse reactions of the two groups were compared. Results After 2 weeks of treatment, the total effective rate of endoscopy in study group was 94.7% higher than that in control group (76.3%), the difference was statistically significant (P <0.05). After complete treatment, the study group’s total clinical effective rate was 97.4% 78.9% higher than the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the study group and the control group (7.9% vs. 7.9%, P> 0.05). Conclusions The application of high-pressure ozone enema combined with mesalazine in the treatment of IBD can significantly improve the efficacy and clinical efficacy of endoscopic examination, without increasing adverse reactions, which is worth popularizing and applying.