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为了解孕产妇分娩前后生长激素(GH)及睾酮(T)水平的变化,本文用放射免疫法对64例年龄在22~35岁,孕期37~42周,出生均为健康儿的孕产妇分娩前及分娩后24小时血清进行了检测,结果显示:血清GH及T水平分娩前均明显高于分娩后及正常未孕组,差异非常显著(P<0.01),而分娩后GH及T水平与正常未孕组无显著性差异(P>0.05)。这是因为一则孕产妇为满足胎儿正常生长发育的需要,分娩前母体垂体及肾上腺功能亢进,GH及T分泌代偿性增高,二则由于胎儿脑垂体生长激素细胞及肾上腺分化较早,并具有分泌功能所至。另外还对怀男胎及怀女胎孕产妇分娩前的睾酮水平进行了统计,统计结果表明,怀男胎孕妇血清T水平明显高于怀女胎的孕妇,差异非常显著(P<0.01)。至于怀男胎母血T浓度增高的原因,主要是由于垂体性腺轴在胚胎时期就有明显的性别差异,雄性胚胎的性腺早期已有分泌睾酮的功能,并与垂体建立了反馈机制,而雌性胚胎的卵巢还处于基本无活动状态。
In order to understand the changes of GH and testosterone levels before and after delivery, 64 pregnant women of 22 to 35 years of age and 37 to 42 weeks of pregnancy with healthy children were given radioimmunoassay Serum levels of serum GH and T were significantly higher 24 h after delivery and before delivery than those after delivery and normal non-pregnant group (P <0.01), but GH and T after delivery There was no significant difference between the level and normal non-pregnant group (P> 0.05). This is because a pregnant woman to meet the needs of the normal growth and development of the fetus, maternal pituitary and adrenal insufficiency before delivery, compensatory increase in GH and T secretion, and second, due to fetal pituitary growth hormone and adrenal cells early differentiation, and Has a secretory function. In addition, the levels of testosterone in maternal and prenatal maternal fetuses before delivery were also calculated. The statistical results showed that the serum T level of maternal and fetal males was significantly higher than that of pregnant women (P <0.01) ). As for pregnant women maternal blood T concentration increased mainly due to the pituitary gland axis in the embryonic period there is a significant gender difference in the early male gonadal secretion of testosterone has been the function and the pituitary to establish a feedback mechanism and the female The embryo’s ovary is still basically inactive.