论文部分内容阅读
目的:探讨玫瑰花总黄酮对脂多糖(LPS)诱导的大鼠乳腺炎的影响。方法:脂多糖注射诱导大鼠乳腺炎,观察玫瑰花总黄酮(200,100 mg·kg~(-1)·d~(-1))给药干预对乳腺组织切片形态学变化、乳腺氧化应激和炎症应激水平的影响。结果:与对照组相比,LPS注射导致大鼠乳腺组织大量炎性细胞浸润,SOD和GPx的活力显著下降,同时MDA水平大幅上升,组织IL~(-1)β、IL-6和TNF-α的水平均显著升高。与模型组比较,低剂量组和高剂量组均能显著改善模型动物乳腺的病理变化,恢复乳腺组织抗氧酶SOD和GPx的活力(P<0.05或P<0.01),降低了MDA的水平(P<0.01),并抑制促炎细胞因子IL~(-1)β、IL-6和TNF-α水平的上升(P<0.05或P<0.01)。结论:玫瑰花总黄酮有潜在的抗乳腺炎活性。
Objective: To investigate the effect of total flavones of rose flower on lipopolysaccharide (LPS) -induced mastitis in rats. Methods: Lipopolysaccharide injection induced mastitis in rats. The effects of total flavonoids of rose flower (200, 100 mg · kg -1 · d -1) on morphological changes of mammary gland tissue sections, mammary gland oxidative stress and The impact of inflammatory stress levels. Results: Compared with the control group, LPS injection resulted in a large number of inflammatory cell infiltration in the mammary gland tissue of rats. The activities of SOD and GPx were significantly decreased. At the same time, the level of MDA increased significantly. The levels of IL-1, IL-6 and TNF- α levels were significantly increased. Compared with the model group, the low dose group and the high dose group could significantly improve the pathological changes of mammary gland, restore the activity of antioxidant enzymes SOD and GPx (P <0.05 or P <0.01) and reduce the level of MDA P <0.01), and inhibited the increase of the levels of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α (P <0.05 or P <0.01). Conclusion: Flavonoids have potential anti-mastitis activity.