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目的探讨帕罗西汀对咽异感症的疗效及安全性。方法选自门诊咽异感症病人共66例,随机分为帕罗西汀组(33例)和丁螺环酮组(33例),疗程6周。采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定临床疗效,副反应量表(TESS)评定副反应。结果帕罗西汀组治疗前后的HAMD及HAMA评分比较有显著性差异(P<0.01),两组间从治疗第2周末起,各时点HAMD评分有显著性差异(P<0.05);两组间HAMA评分在治疗第2周末有显著性差异(P<0.05);在第4、6周末无显著性差异(P>0.05);两组间各时点TESS评分无显著性差异(P>0.05)。结论帕罗西汀在显著改善咽异感症患者抑郁症状的同时,其改善焦虑症状的疗效与抗焦虑药物丁螺环酮相当,疗效较好,副作用小。
Objective To investigate the efficacy and safety of paroxetine in the treatment of pharyngitis. Methods Sixty-six outpatients with pharyngeal seborrhea were randomly divided into paroxetine group (n = 33) and buspirone group (n = 33) for 6 weeks. The Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to evaluate the clinical efficacy and side effects scale (TESS) to evaluate side effects. Results The HAMD and HAMA scores in paroxetine group before and after treatment were significantly different (P <0.01). There was a significant difference in HAMD score between the two groups (P <0.05) There was no significant difference between the two groups at the end of the 4th and 6th week (P> 0.05). There was no significant difference in the TESS score between the two groups at each time point (P> 0.05) . Conclusion Paroxetine can significantly improve the symptoms of patients with pharyngeal dysarthria, while its efficacy of improving anxiety symptoms is comparable to that of buspirone, an anti-anxiety drug with good curative effect and little side effects.