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目的:考察注射用兰索拉唑与注射用氯诺昔康在0.9%氯化钠注射液中的配伍稳定性。方法:在25℃和37℃条件下放置8h,考察配伍后的外观、不溶性微粒、pH变化,并用紫外-可见分光光度法测定兰索拉唑和氯诺昔康的含量。结果:两药配伍后,在25℃条件下配伍液8h内溶液的外观、不溶性微粒、pH及含量均无明显变化;在37℃条件下,配伍液除6h时兰索拉唑含量略有下降,其他指标无明显变化。结论:注射用兰索拉唑与注射用氯诺昔康可与0.9%氯化钠注射液配伍使用,应在6h内用完,配伍液不宜在高温下放置。
Objective: To investigate the compatibility of lansoprazole for injection and lornoxicam for injection in 0.9% sodium chloride injection. Methods: The appearance, insoluble particles and pH of the mixture were observed under the conditions of 25 ℃ and 37 ℃ for 8 hours. The contents of lansoprazole and lornoxicam were determined by UV - visible spectrophotometry. Results: After the two drugs were combined with each other, the appearance, insoluble particles, pH and content of the solution did not change obviously under the condition of 25 ℃. Under the condition of 37 ℃, the content of lansoprazole decreased slightly , Other indicators no significant change. CONCLUSION: Lansoprazole for injection and lornoxicam for injection can be used in combination with 0.9% sodium chloride injection and should be used within 6h. Compatibility solution should not be placed under high temperature.