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目的探讨尾型同源盒转录因子2(Cdx2)在肠型胃癌发生中的作用。方法采用免疫组织化学ABC法检测104例慢性浅表性胃炎、98例慢性萎缩性胃炎、112例胃黏膜肠上皮化生、106例胃黏膜不典型增生和93肠型胃癌组织中Cdx2蛋白的表达。结果Cdx2在慢性浅表性胃炎和慢性萎缩性胃炎组织中无表达,在胃黏膜肠上皮化生、胃黏膜不典型增生和肠型胃癌组织中阳性表达率分别为86.6%(97/112)、58.5%(62/106)和56.9%(53/93)。其中Cdx2在胃黏膜肠上皮化生组织中的蛋白表达阳性率显著高于胃黏膜不典型增生和肠型胃癌组织(P<0.05);在胃黏膜不典型增生与肠型胃癌组织中,Cdx2蛋白表达阳性率差异无统计学意义(P>0.05)。结论Cdx2可能为胃黏膜组织肠上皮化生病变的特异性标志物;Cdx2蛋白过表达在肠型胃癌的发生中发挥重要作用。
Objective To investigate the role of tailed homeobox transcription factor 2 (Cdx2) in the development of intestinal-type gastric cancer. Methods The expression of Cdx2 protein in 104 cases of chronic superficial gastritis, 98 cases of chronic atrophic gastritis, 112 cases of gastric mucosal intestinal metaplasia, 106 cases of gastric mucosa dysplasia and 93 intestinal type gastric carcinoma were detected by immunohistochemical ABC method . Results There was no expression of Cdx2 in chronic superficial gastritis and chronic atrophic gastritis tissues. The positive rates of Cdx2 in gastric mucosal intestinal metaplasia, gastric dysplasia and intestinal type gastric cancer were 86.6% (97/112) 58.5% (62/106) and 56.9% (53/93). The positive rate of Cdx2 in gastric mucosa intestinal metaplasia tissue was significantly higher than that in gastric mucosa dysplasia and intestinal type gastric cancer (P <0.05). In gastric mucosa dysplasia and intestinal type gastric cancer, Cdx2 protein The positive rate of expression was not statistically significant (P> 0.05). Conclusion Cdx2 may be a specific marker of intestinal metaplasia in gastric mucosa. Cdx2 overexpression plays an important role in the development of intestinal-type gastric cancer.