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金霉素治疗急性菌痢,效果良好。但有些学者指出:金霉素可使肝脏的醣元儲备減少,因而有时发生肝脂肪浸潤。动物实驗,由胃腸道外給予大剂量金霉素,則可見肝脏解毒机能減退,且有血清胆醇和胆紅質含量減少及白蛋白、β球蛋白含量降低。有些学者指出金霉素和磺胺类药物并用,可以減少或消除其副作用。著者对207例急性菌痢患者,采用不同的金霉素疗法,并以馬尿酸試驗(Quick-Dytel氏法)来估价治疗过程及治疗后肝脏解毒机能状态。观察結果:大剂量組(全程总量12克)較小剂量
Chlortetracycline treatment of acute bacillary dysentery, the effect is good. However, some scholars pointed out: chlortetracycline can reduce the glycogen reserves of the liver, liver fat infiltration sometimes occurs. Animal experiments, given a large dose of chlortetracycline by the outside of the gastrointestinal tract, we can see the liver detoxification dysfunction, and serum cholesterol and bilirubin levels and albumin, beta globulin content decreased. Some scholars pointed out that chlortetracycline and sulfa drugs used in combination, can reduce or eliminate its side effects. The author of 207 cases of acute dysentery in patients with different chlortetracycline therapy, and hippuric acid test (Quick-Dytel’s method) to evaluate the course of treatment and liver detoxification function status. Observations: high-dose group (total amount of 12 grams) smaller doses