血小板源性生长因子(PDGF)是成纤维细胞,平滑肌细胞以及其它间充质来源细胞的强有丝分裂原和化学驱动剂。同VEGF家族成员类似,PDGF家族每一成员都含有一个高度保守的PDGF/VEGF同源结构域。生物活性PDGF分子一般由二硫键连接的同源二聚体或异源二聚体组成,受体是酪氨酸激酶受体PDGFR-α,β。PDGF及其受体在胚胎发育过程中扮演着非常重要的角色,尤其是肾脏、血管、肺和中枢神经系统。PDGF家族成员目前至少有4个,即PDGF-A,B,C,D。其中PDGF-A,B的研究历史已有二十余年,而PDGF-C,D是近年来刚发现的两个新成员。本综述主要是探讨PDGF-C,D两配体的结构和功能特性,并与两个传统的PDGF分子PDGF-A和PDGF-B加以比较。 Platelet-derived growth factor (PDGF) is a mitogenic and chemical driver of fibroblasts, smooth muscle cells, and other mesenchymal-derived cells. Like members of the VEGF family, each member of the PDGF family contains a highly conserved PDGF / VEGF homology domain. Biologically active PDGF molecules generally consist of disulfide-linked homodimers or heterodimers, which are tyrosine kinase receptors PDGFR-alpha, beta. PDGF and its receptors play a very important role in embryonic development, especially the kidneys, blood vessels, lungs and central nervous system. At present, there are at least 4 PDGF family members, PDGF-A, B, C and D. The research history of PDGF-A and B has been more than twenty years, and PDGF-C and D are two new members just discovered in recent years. This review focuses on the structural and functional properties of PDGF-C and D ligands and compares them with two traditional PDGF molecules, PDGF-A and PDGF-B.