英国研究人员Devereux博士等人最近发现,某些耐药HIV-1毒株的复制能力低于其野生型毒株,从而提示恢复以往失败的治疗方案可能仍然有效。Devereux博士等人推测,具有耐药基因的病毒,其适应能力不如野生型病毒,一旦停止治疗,野生型病毒就会占据优势。为了验证这种假设,他们以11名对多种抗逆转录病毒药物产生耐药并停止治疗的男性HIV-1感染者为研究对象,评估了其治疗前后体内蛋白酶和逆转录酶基因的突变情况,并将治疗结束时突变病毒的消失速度作为病毒相对适合度的指标。结果显示,接受高效抗逆 British researchers Dr. Devereux and others recently found that some strains of resistant HIV-1 replicate less well than their wild-type counterparts, suggesting that the restoration of previously failed treatment regimens may still be effective. Dr. Devereux et al. Hypothesized that viruses with drug-resistant genes would not be as adaptable as wild-type viruses, and wild-type viruses would dominate once treatment was stopped. To test this hypothesis, they evaluated HIV-1 mutations in protease and reverse transcriptase genes in 11 male HIV-1 infected patients who were resistant to multiple antiretroviral drugs and discontinued treatment , And the rate of disappearance of the mutated virus at the end of the treatment was used as an indicator of the relative fitness of the virus. The results show that to accept highly effective resistance