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目的 :应用不同剂量促肝细胞生长素 (c HGF)治疗重型肝炎 96例 ,以评价其疗效。方法 :采取回顾性对照的研究方法。常规剂量 c HGF(80～ 12 0 mg)治疗重型肝炎 48例 ,大剂量 c HGF(2 0 0～ 2 40 mg)治疗重型肝炎 48例 ,以病死率作为判断疗效的指标。结果 :常规剂量组病死率为 45 .8% (2 2 / 48) ,大剂量组病死率为 2 5 .0 % (12 / 48) ,两组间病死率经统计学处理 χ2 =4.5 5 4,P<0 .0 5 ,具有显著性差异。结论 :早期大剂量应用 c HGF治疗重型肝炎能显著降低病死率 ,显示了 c HGF的量效关系 ,无明显副作用 ,值得推广应用。
Objective: To evaluate the curative effect of 96 cases of severe hepatitis treated with different doses of c HGF. Methods: A retrospective study of control methods. Forty-eight cases of severe hepatitis treated with conventional dose of c HGF (80-1200 mg) and 48 cases of severe hepatitis treated with high-dose c HGF (200-240 mg) were selected as the indicators of the therapeutic effect. Results The case fatality rate was 45.8% (22/48) in the conventional dosage group and 25.0% (12/48) in the high-dose group. The mortality of the two groups was statistically calculated as χ2 = 4.55 4 , P <0. 05, with significant difference. Conclusion: The early high-dose c HGF treatment of severe hepatitis can significantly reduce the mortality, showing the dose-response relationship of c HGF, no obvious side effects, it is worth promoting the application.