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在宫内宿主防御机制中,宫内膜T淋巴细胞可能起作用,他们可能与细胞因子分泌有关或起局部抑制细胞的作用。至今多数研究是针对正常妊娠与非妊娠内膜的T细胞在体内功能或内膜与外周血间的T细胞群。 本研究的目的是用免疫组化方法对自然早期流产和正常早孕者的蜕膜T细胞亚群进行计数和比较,以及在总的蜕膜CD3阳性细胞群中CD4和CD8阳性的细胞数和比例,还对T细胞受体(TCR)的表达进行研究。
In intrauterine host defense mechanisms, endometrial T lymphocytes may play a role, and they may be involved in or inhibit the cytokine secretion locally. Most studies to date have focused on the in vivo function of T cells in normal and non-pregnant endometrium or the T cell population between intima and peripheral blood. The purpose of this study was to count and compare the decidual T-cell subsets of patients with early spontaneous abortion and normal pregnancy by immunohistochemistry, and the number and proportion of CD4 and CD8 positive cells in the total decidual CD3 positive cells , T-cell receptor (TCR) expression was also studied.