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肿瘤的发病机理和临床表现与特定的基因重排有关。染色体断裂点的克隆是认识基因重排的一条重要途径。作者通过对1例Invins(10;11)(p12;q23q12)急性髓系白血病(AML)患者的断裂点基因的研究发现,其AF10基因组中倒位插入了MLL和HEAB,并形成两
The pathogenesis and clinical manifestations of tumors are related to specific gene rearrangements. Cloning of chromosome breakpoints is an important way to understand gene rearrangements. The authors studied the gene of breakpoints in a patient with Invins(10;11)(p12;q23q12) acute myeloid leukemia (AML) and found that the MPL and HEAB were inserted in the AF10 genome in an inverted position and formed two