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目的评估PLR和NLR在PCa和BPH初诊患者中筛查PCa患者的价值。方法收集我院2012年至2015年PCa和BPH住院患者96人:分析两组患者初诊PLR,NLR差异性,评估其诊断价值。结果 PCa患者的PLR中位数为103.6(IQR,88.1~120.7),BPH患者的PLR中位数为127.2(IQR,91.0~183.8),PCa初诊患者的PLR明显低于BPH初诊患者(P=0.011);PCa患者NLR中位数1.95(IQR,1.4~2.8),BPH患者NLR中位数2.6(IQR,1.7~4.5),PCa初诊患者NLR明显低于BPH初诊患者(P=0.008);应用ROC曲线分析,PLR的曲线下面积为0.664(95%CI,0.554~0.773),NLR的曲线下面积为0.643(95%CI,0.536~0.750),两指标均具有诊断价值;ROC曲线计算PLR和NLR的最佳cutoff值,PLR小于145,NLR小于2.55作为在PCa和BPH初诊患者中筛查PCa患者的依据,PLR小于145作为诊断标准的敏感度高达92.9%。结论PLR,NLR可作为有价值指标在PCa和BPH初诊患者中筛查PCa患者。
Objective To assess the value of PLR and NLR in the screening of PCa patients in newly diagnosed PCa and BPH. Methods A total of 96 inpatients with PCa and BPH from 2012 to 2015 in our hospital were collected. The differences of newly diagnosed PLR and NLR between the two groups were analyzed to evaluate their diagnostic value. Results The median PLR of PCa patients was 103.6 (IQR, 88.1-120.7). The median of PLR in patients with BPH was 127.2 (IQR, 91.0-183.8). The PLR of newly diagnosed PCa patients was significantly lower than that of newly diagnosed BPH patients (P = 0.011 ). The median NLR of PCa patients was 1.95 (IQR, 1.4-2.8). The median NLR of BPH patients was 2.6 (IQR, 1.7-4.5). The NLR of newly diagnosed PCa patients was significantly lower than that of newly diagnosed BPH patients (P = 0.008) The area under the curve of PLR was 0.664 (95% CI, 0.554-0.773). The area under the curve of NLR was 0.643 (95% CI, 0.536-0.750). Both indexes were of diagnostic value. The ROC curve calculated PLR and NLR The best cutoff value, PLR less than 145, NLR less than 2.55 in PCa and BPH screening of patients with PCa in the basis of screening, PLR less than 145 as the diagnostic criteria of sensitivity up to 92.9%. Conclusion PLR and NLR can be used as valuable indicators in the screening of PCa patients in newly diagnosed PCa and BPH patients.