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2,6-二氨基吡啶是白色的片状晶体,在空气中易氧化而变黑,熔点为119～121℃,是医药、农药、染料、添加剂等生产中不可缺少的重要中间体。传统工艺是以吡啶和氨基钠为起始原料,首先合成α-氨基吡啶,再由α-氨基吡啶合成2,6-二氨基吡啶,该工艺流程长、收率低,仅有47％,没有实用价值。我们尝试利用吡啶和氨基钠为起始原料,在相转移催化剂A作用下,合成2,6-二氨基吡啶,并取得了较为满意的结果,该法具有操作简单、工艺流程短、反应时间少、产率高、成本低等优点,值得工业化推广。1合成原理 利用吡啶和氨基钠合成2,6-二氨基吡啶的化学方程式如下:
2,6-Diaminopyridine is a white flaky crystal that is easily oxidized and darken in the air with a melting point of 119-121 ° C. It is an indispensable and important intermediate in the production of medicines, pesticides, dyes and additives. The traditional process is based on pyridine and sodium amide as the starting material, the first synthesis of α-aminopyridine and then α-aminopyridine synthesis of 2,6-diaminopyridine, the process long, low yield, only 47%, no Practical value. We try to use pyridine and sodium amide as the starting material, under the action of phase transfer catalyst A, 2,6-diaminopyridine was synthesized and the results were satisfactory. The method has the advantages of simple operation, short process flow and less reaction time , High yield, low cost, it is worth industrialization. 1 Synthesis Principle Pyridine and sodium amide synthesis of 2,6-diaminopyridine chemical equation is as follows: