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目的:探讨反复发作性脑梗死患者短期加用氯吡格雷联合阿司匹林抗血小板聚集治疗的有效性。方法:将2012年10月至2014年10月我院神经内科及综合内科收治的反复发作性脑梗死患者82例随机分成氯吡格雷+阿司匹林治疗组(研究组,n=41)和阿司匹林治疗组(对照组,n=41),比较两组住院14日及出院6个月内急性脑梗死的总再次发生率。结果:研究组急性脑梗死总再次发生率明显低于对照组(7.3%vs 22.0%,P<0.05)。结论 :反复发作性脑梗死患者若无禁忌症及患者同意,应尽早行短期应用氯吡格雷联合阿司匹林治疗,以降低急性脑梗死的再次发生率。
Objective: To investigate the effectiveness of short-term anti-platelet aggregation with clopidogrel combined with aspirin in patients with recurrent cerebral infarction. Methods: From October 2012 to October 2014, 82 patients with recurrent cerebral infarction admitted to Department of Neurology and General Internal Medicine in our hospital were randomly divided into clopidogrel + aspirin group (study group, n = 41) and aspirin group (Control group, n = 41). The total recurrence rate of acute cerebral infarction in both groups on the 14th and 6th months after discharge was compared. Results: The recurrence rate of acute cerebral infarction in study group was significantly lower than that in control group (7.3% vs 22.0%, P <0.05). Conclusion: Patients with recurrent recurrent cerebral infarction should be treated with clopidogrel plus aspirin as soon as possible to reduce the recurrence of acute cerebral infarction.