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目的:研究对肾移植术后可溶性HLA-Ⅰ(sHLA-Ⅰ)的含量进行动态监测的意义。方法:采用ELISA双抗夹心法测定血清中sHIA-Ⅰ含量,检测60例正常广东人sHLA-Ⅰ值,观察10例肾移植患者术后血清中sHLA-Ⅰ变化及其临床意义。结果:肾移植患者的sHLA-Ⅰ水平在临床出现急性排斥前1-3天显著增高,应用免疫抑制剂时s HLA-Ⅰ下降;未发生排斥反应者则无明显波动。结论:动态监测sHIA-Ⅰ能预示肾移植排斥的发生,对治疗效果及预后的判断也有重要价值。
Objective: To study the significance of dynamic monitoring of soluble HLA-Ⅰ (sHLA-Ⅰ) content after renal transplantation. Methods: The content of sHIA-Ⅰ in sera was detected by ELISA and the sHLA-Ⅰ in 60 cases of normal Guangdong were detected. The changes of sHLA-Ⅰ in 10 cases of renal transplant recipients and its clinical significance were observed. Results: The levels of sHLA-Ⅰ in renal transplant recipients increased significantly 1-3 days prior to the acute rejection and s HLA-Ⅰ decreased when immunosuppressive agents were used. There was no significant fluctuation in those without rejection. Conclusion: The dynamic monitoring of sHIA-Ⅰ can predict the occurrence of renal allograft rejection and is of great value in judging the therapeutic effect and prognosis.