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肝脏是脂肪代谢的主要器官 ,肝细胞表面的低密度脂蛋白受体 (LDLR)是一种细胞膜表面糖蛋白 ,主要的生物学功能是介导低密度脂蛋白 (LDL)进入细胞 ,调节胆固醇的代谢 ,在脂肪代谢中起重要作用。LDLR突变能严重影响体内脂肪代谢 ,从而诱发家族性高胆固醇血症 ,能导致未成年期冠状
The liver is the main organ of fat metabolism. The low density lipoprotein receptor (LDLR) on the surface of liver cells is a kind of cell surface glycoprotein. Its main biological function is to mediate the entry of low density lipoproteins (LDLs) into cells and the regulation of cholesterol Metabolism plays an important role in fat metabolism. LDLR mutations can seriously affect the body’s fat metabolism, which induced familial hypercholesterolemia, can lead to coronary juvenile