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目的观察步长稳心颗粒联合心得安对Graves病引起的心动过速及房颤的临床疗效。方法 78例Graves病伴心动过速及房颤患者被随机分为对照组和观察组,各39例,两组均给予甲巯咪唑、盐酸普萘洛尔治疗,观察组在此基础上给予稳心颗粒辅助治疗心律失常。观察两组患者疗效及不良反应发生率。结果对照组显效12例(32.4%),有效13例(35.2%),总有效率为67.6%,观察组显效17例(44.7%),有效16例(42.1%),总有效率为86.8%,两组疗效差异有统计学意义(χ2=3.97,P=0.04),观察组高于对照组。两组患者细胞减少、皮疹、胆汁淤积性黄疸及急性关节痛等主要并发证发生率上差异无统计学意义(P>0.05)。结论采用步长稳心颗粒联合心得安治疗Graves病引起的快速型心律失常,并发现步长稳心颗粒确实可提高甲亢性心律失常治疗的总有效率,且并不增加治疗过程中的不良反应,可在临床工作中推广使用。
Objective To observe the clinical effect of step-stabilizing granule combined with propranolol on tachycardia and atrial fibrillation caused by Graves disease. Methods 78 cases of Graves’ disease with tachycardia and atrial fibrillation were randomly divided into control group and observation group, 39 cases in each group. Both groups were given methimazole and propranolol hydrochloride. The observation group was given stable Heart particles assist in the treatment of arrhythmias. The curative effect and incidence of adverse reactions in two groups were observed. Results The control group was significantly improved in 12 cases (32.4%), effective in 13 cases (35.2%), the total effective rate was 67.6%, the observation group was markedly effective in 17 cases (44.7%), effective in 16 cases (42.1%), the total effective rate was 86.8% , The difference between the two groups was statistically significant (χ2 = 3.97, P = 0.04), the observation group was higher than the control group. There was no significant difference in the incidence of major complications such as cellular reduction, rash, cholestatic jaundice and acute joint pain in both groups (P> 0.05). Conclusion The step-stabilizing granule combined with propranolol in the treatment of tachyarrhythmia caused by Graves disease, and found that step-stabilizing particles can indeed improve the total effective rate of hyperthyroid arrhythmia treatment, and does not increase the adverse reactions in the course of treatment , Can be used in clinical work.