论文部分内容阅读
目的:对1993年～1998年临床分离致病菌耐药监测结果作综合分析,为临床合理使用抗生素提供科学依据。方法:用纸片扩散法测定细菌对抗生素的耐药性,并用WHONET软件作分析。结果:共收集4675株临床分离细菌作分析。耐甲氧西林葡萄球菌(MRS)分离率6年以来分别为38％、42％、47％、52％、56％、58％,MRS株耐药率远高于甲氧西林敏感株(MSS);耐万古霉素肠球菌分离率为5％,屎肠球菌耐药率远高于粪肠球菌;大肠埃希菌和肺炎克雷伯菌是产超广谱酶(ESBL)的代表株,约为5％,ESBL菌株应报告所有三代头孢菌素和氨曲南耐药,含酶抑制剂的复方制剂对其有较好的抗菌活性;对嗜麦芽窄食单胞菌敏感性较好的抗生素分别为多西霉素、替卡西林/克拉维酸和复方新诺明;鲍曼不动杆菌对含舒巴坦的复方制剂有较好的敏感率;对绿脓假单胞菌治疗应参考本单位药敏试验作出决定;淋病奈瑟菌对头孢曲松耐药率达24％,对环丙沙星耐药率达72％。结论:细菌耐药性逐年增长,耐药监测十分必要。
OBJECTIVE: To comprehensively analyze the drug resistance surveillance results of pathogenic bacteria isolated from 1993 to 1998, and provide a scientific basis for clinical rational use of antibiotics. Methods: Bacterial resistance to antibiotics was determined by disk diffusion method and analyzed by WHONET software. RESULTS: A total of 4675 clinically isolated bacteria were collected for analysis. MRS isolates were 38%, 42%, 47%, 52%, 56% and 58% respectively over 6 years. MRS strains were much more resistant than methicillin sensitive strains (MSS) ; Vancomycin-resistant enterococci isolation rate of 5%, Enterococcus faecium resistant rate is much higher than Enterococcus faecalis; Escherichia coli and Klebsiella pneumoniae is producing ESBL representative strain, about Is 5%, ESBL strains should report all third-generation cephalosporins and aztreonam resistance, compound inhibitors containing enzyme inhibitors have good antibacterial activity; Stenotrophomonas maltophilia sensitive antibiotics Respectively, doxycycline, ticarcillin / clavulanic acid and cotrimoxazole; Acinetobacter baumannii compound containing sulbactam have a better sensitivity; Pseudomonas aeruginosa treatment should be referred to The unit drug sensitivity test to make a decision; Neisseria gonorrhoeae resistance to ceftriaxone 24%, ciprofloxacin resistance rate of 72%. Conclusion: The drug resistance of bacteria increases year by year, and drug resistance monitoring is very necessary.