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光敏化氧化反应是指光敏剂在光作用下氧化底物的过程,它是近年来兴起的光动力学疗法的基础。酞菁化合物与卟啉结构相似,在近红外区(600～700 nm)有很强的吸收,无毒,光与热稳定性好,是很好的敏化剂,某些酞菁能选择性地滞留在肿瘤组织中,对肿瘤细胞有较强的杀伤能力,磺化铝酞菁在水溶液中不聚集,是有应用前景的光动力试剂。磺化酞菁类染料对L-色氨酸的氧化主要是~1O_2反应,但与短肽化合物相互作用的研究较少。本文利用自行合成的磺化铝酞菁研究了它与甘氨酰-L-色氨酸的光敏化氧化动力学,并对其反应机制进行了推断。
Photo-sensitized oxidation refers to the photosensitizer oxidizes the substrate under the action of light, which is the basis of photodynamic therapy that has arisen in recent years. Phthalocyanine is similar in structure to porphyrin, has strong absorption in the near infrared region (600-700 nm), is non-toxic, has good light and thermal stability and is a good sensitizer. Some phthalocyanines can be selectively To stay in the tumor tissue, the tumor cells have a strong killing ability, sulfonated aluminum phthalocyanine does not accumulate in aqueous solution, is a promising photodynamic agent. Sulfonated phthalocyanine dyes on L-tryptophan oxidation is mainly ~ 1O_2 reaction, but less interaction with short peptide compounds. In this paper, the photosensitized oxidation kinetics of glycopyrrole-L-tryptophan with its own synthesis of sulfonated aluminum phthalocyanine was studied and its reaction mechanism was inferred.