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NLRP3(NOD-,LRR,and pyrin domain-containing 3)炎症小体能够对多种病原体保守结构和内源性危险信号应答而活化Caspase-1,介导促炎症细胞因子前体Pro-IL-1β和Pro-IL-18的成熟与分泌,启动免疫防御,在抗微生物感染中发挥着重要作用。该文总结了流感病毒的结构与变异、细胞对流感病毒的识别、流感病毒感染过程中NLRP3炎症小体的活化与功能、流感病毒对免疫识别的逃逸等内容。
The inflammasome of the NLRP3 (NOD-, LRR, and pyrin domain-containing 3) activates Caspase-1 in response to the conserved structural and endogenous danger signals of a variety of pathogens, mediates the pro-IL-1β pro-inflammatory cytokine precursor And Pro-IL-18 maturation and secretion, start the immune defense, play an important role in antimicrobial infections. This article summarizes the structure and variation of influenza virus, the identification of influenza virus in cells, the activation and function of NLRP3 inflammasome in influenza virus infection, the escape of influenza virus to immune recognition and so on.