临床上常常将使用标准剂量激素 (强的松 1mg·kg- 1·d- 1)治疗肾病综合征 (NS) 3～ 6月后 ,症状仍不缓解或反而加重的患者 ,称为难治性肾病综合征(RNS)。据不完全统计RNS发生率约 30 % [1,2 ] 。因此 ,RNS是临床上常见的难治性病症之一 ,往往给临床医生带来极大困难。本院肾内 Clinically, the standard dose of hormone (prednisone 1 mg · kg-1 · d-1) will often be used in patients with nephrotic syndrome (NS) 3 to 6 months after the symptoms remain or not exacerbated, called refractory kidney disease Syndrome (RNS). According to incomplete statistics about the incidence of RNS about 30% [1,2]. Therefore, RNS is one of the most common clinical refractory diseases, which often brings great difficulties to clinicians. Our hospital kidney