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人类免疫缺失病毒(HIV)在非分裂细胞如终末分化巨噬细胞的复制可能对它在人体内的运输,扩散、存留以及对艾滋病的诱导是非常重要的。与致癌逆转录病毒相反,HIV能感染非增殖的靶细胞,因为它编码一些控制病毒核蛋白复合体主动穿过核孔的决定因子,能在不发生有丝分裂的情况下整合到宿主细胞染色体。病毒基质蛋白(MA)和Vpr这两个病毒蛋白介导这个过程。MA是HIV-1 P53 Gag
The replication of human immunodeficiency virus (HIV) in non-dividing cells, such as terminally differentiated macrophages, may be important for its transport, spread, retention and induction of AIDS in humans. In contrast to oncogenic retroviruses, HIV infects non-proliferating target cells because it encodes determinants that control the viral nucleoprotein complex actively passing through the nuclear pore and integrates into host cell chromosomes without mitosis. Two viral proteins, the viral matrix protein (MA) and Vpr, mediate this process. MA is HIV-1 P53 Gag