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在机体的适应性免疫应答中,CD4+T细胞作为效应T细胞的主要成员,参与免疫应答的各个阶段,能协调固有免疫和适应性免疫系统的功能与活化,在免疫调节中发挥关键作用。根据产生细胞因子和发挥生物功能的不同,将CD4+T细胞分为Th1、Th2辅助细胞和调节性T细胞(Treg)三个亚群[1-2],它们在免疫过程中相互调节并相互制约。Th1细胞分泌IFN-γ、IL-12等细胞因子,在抗肿瘤、清除胞内病原微生物等方面发挥作用;Th2细胞则通
In the body’s adaptive immune response, CD4 + T cells, as major members of effector T cells, participate in all stages of the immune response and can coordinate innate and adaptive immune system functions and activation, playing a key role in immune regulation. CD4 + T cells are divided into three subsets of Th1, Th2 helper cells and regulatory T cells (Treg) according to the different cytokines and biological functions [1-2]. They regulate each other and interact with each other Restrictions. Th1 cells secrete IFN-γ, IL-12 and other cytokines, which play an important role in anti-tumor and clearance of intracellular pathogenic microorganisms. Th2 cells pass