目的探讨慢性肾功能衰竭并发急性胰腺炎时的临床特点及发病机制。方法回顾分析中南大学湘雅二院1998-01~2004-05共23例患者的临床资料。结果慢性肾功能衰竭并发急性胰腺炎时,部分患者临床表现不典型;患者系统并发症及病死率高,预后差。结论临床医师应重视对该病的认识、诊断与治疗,并应进一步加强对该病发病机制的研究。 Objective To investigate the clinical features and pathogenesis of chronic renal failure complicated with acute pancreatitis. Methods The clinical data of 23 patients from 1998 to 2004 in Xiangya Hospital of Central South University were retrospectively analyzed. Results Chronic renal failure complicated by acute pancreatitis, some patients with atypical clinical manifestations; patients with high rates of systemic complications and mortality, the prognosis is poor. Conclusion Clinicians should pay attention to the recognition, diagnosis and treatment of the disease, and should further strengthen the study of the pathogenesis of the disease.