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采用整体大鼠心肌缺血再灌注模型,观察1-肉桂基-4-(2,3,4-三甲氧基苄基)-四氢吡嗪盐酸盐(CTTP)对缺血再灌性心律失常的保护作用.于结扎前3min,CTTP2.5或5mg·kg-1iv,可显著降低缺血再灌损伤引起的室性心律失常发生率,缩短持续时间;能明显减少心肌谷草转氨酶,肌酸激酶和乳酸脱氢酶释放量;升高超氧化物歧化酶活性,减少脂质过氧化反应代谢产物丙二醛含量.提示CTTP抗心肌缺血再灌注心律失常的作用,可能与降低心肌脂质过氧化和增强氧自由基清除酶的活性有关.
The rat model of myocardial ischemia reperfusion was used to observe the effect of 1-cinnamyl-4- (2,3,4-trimethoxybenzyl) -tetrahydropyrazine hydrochloride (CTTP) on ischemia-reperfusion arrhythmia Abnormal protection. 3min before ligation, CTTP2.5 or 5mg · kg-1iv, can significantly reduce the incidence of ventricular arrhythmia caused by ischemia-reperfusion injury and shorten the duration; can significantly reduce myocardial aspartate aminotransferase, creatine kinase and lactate dehydrogenation Enzyme release; increase superoxide dismutase activity, reduce lipid peroxidation metabolites malondialdehyde content. Tip CTTP anti-myocardial ischemia-reperfusion arrhythmia may be related to reducing myocardial lipid peroxidation and enhance the activity of oxygen free radical scavenging enzymes.