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目的分析脑铁含量与帕金森病的关系。方法选取帕金森病患者50例为观察组,同期健康体检者50例为对照组,入选者均以磁共振磁敏感加权成像技术对感兴趣区域(ROI)的相位值进行测定,分析其与患者脑内铁沉积含量间的关系,探究脑铁含量与帕金森病病症指标相关性。结果观察组SNc-中、SNr-中、SNr-侧相位值均小于对照组(P<0.05);黑质相位值SNc-中、SNr-中和SNr-侧与Hoehn-Yahr分期呈负相关。结论帕金森病患者的黑质,特别是黑质网状致密带的铁沉积多于常人,其含量与患者运动功能障碍严重程度有关。磁共振对铁敏感,以加权成像联合小密度投影可较为准确的测定患者脑铁含量,能够为临床监测帕金森病情进展提供参考,值得临床推广应用。
Objective To analyze the relationship between brain iron content and Parkinson’s disease. Methods Fifty patients with Parkinson’s disease were selected as the observation group and 50 healthy subjects were selected as the control group during the same period. The magnetic resonance susceptibility weighted imaging technique was used to determine the phase value of ROI. Brain iron deposition in the relationship between content of brain iron content and Parkinson’s disease disease index correlation. Results The SNc-SNr-phase and SNr-phase in the observation group were significantly lower than those in the control group (P <0.05). The SNc-SNr-neutralizing SNr-side of the substantia nigra phase was negatively correlated with the Hoehn-Yahr stage. Conclusion Parkinson’s disease in patients with substantia nigra, especially the substantia nigra mesh dense deposits of iron deposition than the average person, its content and the severity of motor dysfunction in patients. Magnetic resonance is sensitive to iron. Weighted imaging combined with small density projection can be more accurate determination of brain iron content in patients with Parkinson’s disease progression for clinical monitoring to provide a reference, worthy of clinical application.