论文部分内容阅读
2-氯 - 3-氨基吡啶 ( 1 )为一重要的医药中间体 ,用来合成抗消化性溃疡药哌仑西平[1] 、二氮杂类抗艾滋病药 [2～ 4 ] ,并可用作杀虫剂的中间体 [5]。文献报道 1可用 2 -氯烟酰胺为原料进行霍夫曼降解[6] ,或氯化亚锡还原 2 -氯 - 3-硝基吡啶[7] 等方法来制备 ,但所用原料来?
2-Chloro-3-aminopyridine (1) is an important pharmaceutical intermediate for the synthesis of pirenzepine [1], a diazepam anti-AIDS drug [2 ~ 4] Used as an insecticide intermediate [5]. Reported in the literature 1 available 2 - chloronicotinamide Huoffman degradation of raw materials [6], or stannous chloride reduction 2 - chlorine - 3 - nitropyridine [7] and other methods to prepare, but the raw materials used to?