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我们应用免疫组化方法结合形态观察，对大鼠实验性肝、肺和肾小球的纤维化、硬化过程中的细胞外基质（ＥＣＭ－ＦＮ，ＬＮ，ＣｏｌⅠ、Ⅲ、Ⅳ、Ⅴ）；以及肝脏的Ｉｔｏ细胞、肺泡壁原始间叶细胞（ＰＭＣ）和肾小球系膜细胞的骨架蛋白（ＤＭ、ＶＭ、α—ＳＭＡ）表型变化，进行了动态的对比研究，发现在纤维化硬化过程中，上述三种细胞大量增生并伴细胞骨架蛋白表型和ＥＣＭ分泌的系列改变。同时对此类细胞在修复过程中演变的共同规律和某些特殊规律、作用和意义，作了探索性的讨论。
We used immunohistochemistry and morphological observation to observe the changes of fibrosis and extracellular matrix (ECM-FN, LN, ColⅠ, Ⅲ, Ⅳ, Ⅴ) in experimental liver, lung and glomeruli in rats; The changes of the phenotypes of hepatic Ito cells, primitive mesenchymal cells in the alveolar wall (PMC) and mesangial cells (DM, VM, α-SMA) were studied dynamically and found that in the process of fibrosis , The above three cell hyperplasia with a series of changes in cytoskeletal phenotype and ECM secretion. At the same time, the common law and some special laws, functions and significances of the evolution of such cells in the process of restoration are explored.