论文部分内容阅读
目的研究吉非替尼(Iressa)与顺铂(cisplatin,DDP)联用对舌鳞状细胞癌(简称鳞癌)Tscca移植瘤的体内抑制作用,探讨Iressa在头颈鳞癌治疗中的价值。方法用中国人舌鳞癌细胞系Tscca接种2只雌性裸鼠,成瘤后取其肿瘤组织置入48只4～5周龄的裸鼠腋窝皮下,次日随机分组并治疗。Iressa以灌胃给药方式,DDP以腹腔注射方式。药物处理前和处理后隔日测量肿瘤的长、宽最大直径计算肿瘤体积;用药结束后2天处死荷瘤鼠称瘤重,计算抑瘤率。结果对照组肿瘤生长快于治疗组,但是吉非替尼两个单药组与对照组间差异无统计学意义。对照组肿瘤生长速度与Iressa 100mg/kg+DDP(同时)、Iressa100mg/kg+DDP(异时)和DDP3组差异均有统计学意义(P<0.05),而后三者间差异无统计学意义。结论在本实验设计的条件下Iressa对Tscca移植瘤生长抑制作用较弱,其与DDP联用未见发挥协同作用。
Objective To study the inhibitory effect of Iressa combined with cisplatin (DDP) on Tca cell in tongue squamous cell carcinoma (Squamous cell carcinoma) and to investigate the value of Iressa in the treatment of squamous cell carcinoma of the head and neck. Methods Two female nude mice were inoculated with Chinese tongue squamous cell carcinoma cell line Tscca. Tumor tissues of 48 female nude mice aged 4-5 weeks were inoculated subcutaneously into the tumor tissue and were randomly divided into groups and treated on the following day. Iressa to intragastric administration, DDP by intraperitoneal injection. Before treatment and after treatment, the length and width of the tumor were measured, and the tumor volume was calculated. After 2 days of treatment, tumor-bearing mice were sacrificed to calculate the tumor inhibition rate. Results The tumor growth in the control group was faster than that in the treatment group, but there was no significant difference between the two monotherapy groups and the control group. The growth rate of tumor in control group was significantly different from that of Iressa 100 mg / kg + DDP, Iressa 100 mg / kg + DDP and the DDP3 group (P <0.05). There was no significant difference between the three groups. Conclusions Iressa has a weak inhibitory effect on the growth of Tscca xenografts in this experimental design, and no synergistic effects have been found with it in combination with DDP.