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目的:探讨高原地区慢性胃炎高发病率发病机制。方法:检测高原与平原地区汉族人群慢性胃炎胃组织内一氧化氮(NO)含量。结果:高原地区世居与移居汉族人群胃黏膜组织中的NO含量显著低于平原地区世居汉族人群。同一海拔地区(高海拔地区)世居与移居汉族人群胃黏膜内NO含量无明显差异。结论:高原地区慢性胃炎高发机制之一是因为长期持续处于慢性缺氧状态下胃组织保护性NO显著降低,削弱了其扩张血管,改善胃黏膜微循环的生理功能所致。
Objective: To explore the pathogenesis of high incidence of chronic gastritis in plateau. Methods: The content of nitric oxide (NO) in the stomach tissue of chronic gastritis in Han nationality in plateau and plain areas was detected. Results: The content of NO in gastric mucosa of native and immigrant Han people in plateau area was significantly lower than that of native Han population in plain area. There was no significant difference in the content of NO in the gastric mucosa among the population living and migrating in the same elevation area (high altitude area). CONCLUSION: One of the mechanisms of chronic gastritis in plateau is that the long-term chronic hypoxia-induced decrease of protective nitric oxide (NO) in the gastric tissue weakens its dilation of blood vessels and improves the physiological function of gastric mucosal microcirculation.