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目的:分析炎见宁不良反应(ADR)的发生特点、相关因素及临床转归,为临床合理用药提供依据。方法:对2005年1月1日至2015年3月31日以来我院上报的炎见宁ADR报告进行分析汇总,对其发生机制进行探讨。结果:我院炎见宁ADR发生率为0.87%;男性患者发生率稍高于女性患者;50.00%的ADR发生于大于61岁年龄段患者;71.43%的ADR发生于合并用药患者;66.67%的ADR发生于用药4 d以内,且主要表现为皮肤及其附件损害(32.72%);发生严重不良反应3例(包括2例过敏性休克,1例药物性肝炎)。结论:炎见宁的ADR时有发生且发生机制复杂,临床应用时应密切关注患者状态变化,保证用药安全。
Objective: To analyze the occurrence characteristics, related factors and clinical outcome of Adriamycin-induced adverse reactions (ADRs), so as to provide basis for clinical rational drug use. Methods: The ADR reports of Yiminning reported in our hospital from January 1, 2005 to March 31, 2015 were analyzed and summarized, and their mechanisms were discussed. Results: The incidence of ADR was 0.87% in our hospital. The incidence of male patients was slightly higher than that of female patients. The incidence of ADR in 50.00% occurred in patients older than 61 years old. 71.43% occurred in patients with combined ADR. 66.67% ADR occurred within 4 days after treatment, and mainly manifested as skin and its accessories damage (32.72%); serious adverse reactions in 3 cases (including 2 cases of anaphylactic shock, 1 case of drug-induced hepatitis). Conclusion: The ADR of Yimianning occurs frequently and its mechanism is complicated. The clinical application should pay close attention to the change of the state of the patient and ensure the safety of medication.