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半乳糖凝集素(galectin)是一个广泛分布于微生物、植物和动物(包括寄生虫)中的蛋白家族。随着后基因组学和功能蛋白质组学研究的深入,作为寄生虫感染和免疫中发挥重要作用的虫源性分子,galectin引起越来越多研究者的关注。本文综述了近年来发现的虫源性galectin及其在寄生虫入侵、移行、致病和免疫逃避中作用的研究进展。
Galectins are a family of proteins widely found in microorganisms, plants and animals, including parasites. With the deepening of post-genomics and functional proteomics research, galectin has attracted more and more researchers’ attention as an insect-derived molecule that plays an important role in parasitic infection and immunity. This review summarizes the recent advances in the research on the etiological agents galectin and their roles in invasion, migration, pathogenicity and immune evasion of parasites.