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目的观察多西紫杉醇联合顺铂治疗晚期乳腺癌的疗效及不良反应。方法其中多西紫杉醇60-75mg/m2 dl、顺铂30mg/m2、第2-4d静脉滴注,21-28d为1周期,每例患者治疗2个周期以上。结果完全缓解1例、部分缓解11例、稳定6例、进展3例,总有效率57．1％。初治组有效率83．3％,复治组有效率46．6％。最常见的不良反应为骨髓抑制,其余不良反应均轻微。结论多西紫杉醇联合顺伯治疗晚期乳腺癌有较好的疗效。
Objective To observe the efficacy and adverse reactions of docetaxel combined with cisplatin in the treatment of advanced breast cancer. Methods Docetaxel 60-75mg / m2 dl, cisplatin 30mg / m2, 2-4d intravenous infusion, 21-28d for the 1 cycle, each patient treated more than 2 cycles. The results of complete remission in 1 case, partial remission in 11 cases, stable in 6 cases, 3 cases of progress, the total effective rate was 57.1%. The effective rate was 83.3% in primary treatment group and 46.6% in retreatment group. The most common adverse reactions were myelosuppression, and the remaining adverse reactions were mild. Conclusion Docetaxel combined with cisplatin has a good effect on advanced breast cancer.