目的:探究血塞通对糖尿病视网膜病变(DR)患者视网膜微循环的影响。方法:收集2013年2月至2016年2月在我院接受治疗的95例双眼糖尿病视网膜病变患者,并随机分为对照组(48例)和观察组(47例)。对照组患者给予常规降糖治疗,观察组在对照组的基础上给予血塞通治疗。观察比较两组治疗前后的视网膜微循环指标,包括视网膜中央动脉(CRA)的舒张末期血流速度(EDV)、收缩期峰值流速(PSV)及阻力指数(RI)以及视网膜中央静脉(CRV)的最低血流速度(Vmin)、最高血流速度(Vmax)及平均血流速度(MV),血液流变学指标包括全血低切黏度(NBL)、全血高切黏度(NBH)、红细胞变形指数(DE)、红细胞压积(Hct)、红细胞聚集指数(AE)及血沉(ESR)以及临床疗效。结果:治疗后,观察组的临床总有效率为87.8%,明显高于对照组的61.4%(P<0.05),对照组的EDV、Vmax、Vmin均较治疗前明显改善(P<0.05),NBL和NBH较治疗前明显降低,且观察组的PSV、EDV明显高于对照组,而MV、RI、Vmax、Vmin均低于对照组(P<0.05),NBL、NBH、DE、Hct、AE及ESR均较治疗前明显改善,且相较于对照组改善幅度更显著(P<0.05)。结论:血塞通联合常规降糖治疗糖尿病视网膜病变患者的疗效显著,可有效改善患者的视网膜微循环和血液流变学。 Objective: To investigate the effect of Xuesaitong on the retinal microcirculation in patients with diabetic retinopathy (DR). Methods: A total of 95 patients with binocular diabetic retinopathy treated in our hospital from February 2013 to February 2016 were randomly divided into control group (48 cases) and observation group (47 cases). Patients in the control group were given conventional hypoglycemic treatment, and the observation group was given Xuesaitong treatment on the basis of the control group. The indexes of retinal microcirculation, including end-diastolic velocity (EDV), peak systolic velocity (PSV), resistance index (RI) and central retinal vein (CRV) of central retinal artery Vmin, Vmax and MV, hemorheological indexes including whole blood low shear viscosity (NBL), whole blood high shear viscosity (NBH), erythrocyte deformation Index (DE), hematocrit (Hct), erythrocyte aggregation index (AE) and erythrocyte sedimentation rate (ESR), and clinical efficacy. Results: After treatment, the total clinical effective rate in the observation group was 87.8%, significantly higher than that in the control group (61.4%, P <0.05). The EDV, Vmax and Vmin in the control group were significantly improved (P <0.05) NBL, NBH, DE, Hct, AE were significantly lower than those before treatment, and the PSV and EDV in the observation group were significantly higher than those in the control group (P <0.05) And ESR were significantly improved than before treatment, and compared with the control group improved more significantly (P <0.05). Conclusion: Xuesaitong combined with conventional hypoglycemic treatment of diabetic retinopathy patients with significant effect, can effectively improve the patient’s retinal microcirculation and hemorheology.