目的:探讨γ-生育三烯酚(γ-tocotrienol)对人胃癌细胞SGC-7901抑制作用。方法:采用离体细胞培养技术,利用细胞生长曲线,单细胞凝胶电泳、琼脂糖凝胶电泳、透射电镜技术等方法,观察γ-生育三烯酚对SGC-7901细胞生长抑制及其肿瘤细胞的损伤作用。结果:γ-生育三烯酚可明显抑制SGC-7901细胞增殖,抑制作用随作用浓度增加、作用时间延长而增强;并能引起人胃癌细胞株SGC-7901细胞DNA分子的损伤以及细胞超微结构变化,如线粒体损伤和形成凋亡小体,且与γ-生育三烯酚作用的浓度存在一定的相关性。结论:γ-生育三烯酚对SGC-7901细胞生长有明显抑制作用,其抑制机制与参与DNA损伤、诱导细胞凋亡有关。 Objective: To investigate the inhibitory effect of γ-tocotrienol on human gastric cancer cell line SGC-7901. Methods: The growth inhibition of SGC-7901 cells and the growth of tumor cells by γ-tocotrienol were observed by cell growth curve, single cell gel electrophoresis, agarose gel electrophoresis and transmission electron microscopy Damage effect. Results: γ-tocotrienol significantly inhibited the proliferation of SGC-7901 cells. The inhibitory effect of SGC-7901 cells was increased with the increase of concentration and time. The DNA damage of SGC-7901 cells and the ultrastructure of cells Changes, such as mitochondrial damage and the formation of apoptotic bodies, and the concentration of γ-tocotrienol concentration there is a certain correlation. Conclusion: γ-tocotrienol significantly inhibits the growth of SGC-7901 cells. The mechanism of its inhibition is related to DNA damage and induction of apoptosis.