慢性阻塞性肺疾病(COPD)是一种重要的慢性呼吸系统疾病，其基础和临床研究越来越广泛，目前国内虽然有慢性支气管炎(慢支)动物模型的文献报道，但均未能证实其有气流阻塞，因此，不能称之为COPD。我们采用组织学检查和肺功能测定的方法对吸入高浓度SO2气体诱导的大鼠COPD模型进 Chronic obstructive pulmonary disease (COPD) is an important chronic respiratory disease, its basic and clinical research is more and more widespread, although the current domestic chronic bronchitis (chronic bronchitis) animal models reported in the literature, but failed to confirm It has clogged airflow and, therefore, can not be called COPD. We used histological examination and pulmonary function tests for inhaled high concentrations of SO2 gas-induced rat COPD model