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去极化和非去极化肌松药对新生儿和婴幼儿的作用不同于成年人,造成差别的原因已经探索了近25年。神经肌肉接点物理和化学的成熟,骨骼肌收缩特性的演变,以及体重与肌肉增量的相对比例,在整个童年期都在不断地变化。此外,在整个童年期使用肌松药后的表观分布容积、肌松药的代谢、再分布和排泄(廓清)也都在变化着。其中任何因素对婴幼儿使用肌松药的剂量一效应关系都产生影响。神经肌肉系统一、结构和功能的发育人类和其它动物一样,出生时神经肌系
Depolarized and non-depolarizing muscle relaxants play a different role in newborns and infants than adults and the reason for the difference has been explored for nearly 25 years. The physical and chemical maturation of neuromuscular junctions, the evolution of skeletal muscle contractile properties, and the relative proportions of body weight and muscle mass are constantly changing throughout childhood. In addition, the apparent volume of distribution of muscle relaxants throughout childhood also changes the metabolism, redistribution and excretion (clearance) of muscle relaxants. Any of these factors have an effect on the dose-response relationship of muscle relaxants in infants and young children. Neuromuscular system First, the structure and function of human development and other animals, like, at birth, neuromuscular