新生儿败血症是新生儿期常见而病死率较高的疾病,由于缺乏特征性症状,诊断依赖血培养,不易早期确诊。近年来,国外特别是欧洲各国和日本采用急性时相蛋白(acute Phaseproteins)作为早期诊断新生儿败血症的有效方法。急性时相蛋白是正常血清中蛋白成份,在肝内合成,当细菌感染时,机体除表现局部炎症反应外,这一类蛋白如C-反应蛋白、α_1-酸性糖蛋白、α_1-抗胰蛋白酶、结合珠蛋白等在肝内合成显著增加,在血液中浓 Neonatal sepsis is a common and high mortality in neonatal diseases, due to the lack of characteristic symptoms, diagnosis is dependent on blood culture, not easy to early diagnosis. In recent years, foreign countries, especially European countries and Japan adopt acute phaseproteins as an effective method for early diagnosis of neonatal sepsis. Acute phase proteins are normal serum protein components, synthesized in the liver, when the bacteria are infected, the body in addition to the performance of local inflammatory response, this type of protein such as C-reactive protein, alpha 1-acid glycoprotein, alpha 1-antitrypsin , Haptoglobin and other intrahepatic synthesis increased significantly, concentrated in the blood