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目的:探讨妊娠与系统性红斑狼疮的相互影响。方法:对2002年1月～2009年12月南昌大学医学院第一附属医院收治的25例妊娠合并系统性红斑狼疮患者的临床资料进行回顾性分析。结果:25例患者中,发热5例,关节炎2例,尿常规异常10例,抗核抗体阳性20例,抗Ds-DNA抗体阳性12例,浆膜炎2例,贫血18例,妊娠期高血压疾病3例,肾功能损害2例。25例患者中,处于缓解期9例,均未发现SLE活动指标;处于控制期11例,孕期均未出现病情恶化;活动期患者3例。妊娠期系统性红斑狼疮病情恶化率及不良妊娠结局与妊娠期系统性红斑狼疮病情活动和缓解有关。结论:妊娠期系统性红斑狼疮病情易加重,且易出现不良妊娠结局。
Objective: To investigate the interaction between pregnancy and systemic lupus erythematosus. Methods: The clinical data of 25 cases of pregnancy complicated with systemic lupus erythematosus (SLE) admitted to the First Affiliated Hospital of Nanchang University School of Medicine from January 2002 to December 2009 were analyzed retrospectively. Results: Among the 25 patients, there were 5 cases of fever, 2 cases of arthritis, 10 cases of abnormal urine, 20 cases of anti-nuclear antibodies, 12 cases of anti-Ds-DNA antibodies, 2 cases of serositis, 18 cases of anemia, 3 cases of hypertension, 2 cases of renal dysfunction. Among the 25 patients, none of the 9 patients were in remission, and no SLE activity index was found. Among the 25 patients, 11 were in control and none were worse during pregnancy; 3 patients were active. Deterioration of pregnancy rates of systemic lupus erythematosus and adverse pregnancy outcomes with systemic lupus erythematosus in pregnancy disease activity and mitigation. Conclusion: The condition of systemic lupus erythematosus in pregnancy is easy to aggravate, and prone to adverse pregnancy outcomes.