帕金森病（ＰＤ）有明显的认知障碍，在早期ＰＤ患者中主要表现为执行能力下降、视空间障碍、记忆力下降、定势转换障碍，而在晚期主要表现为痴呆。ＰＤ患者的认知障碍与发病年龄、起病侧、运动症状的表现有关，微电极引导的丘脑或苍白球毁损术对认知障碍的影响较小，而多类药物治疗均对ＰＤ患者的认知功能产生影响，揭示ＰＤ患者认知改变的复杂生化基础。 Parkinson’s disease (PD) has obvious cognitive impairment, which is mainly manifested in the early stage of PD patients as decreased ability to conduct, visual space disorders, memory loss, set-back transition disorder, and mainly in the late stage of dementia. PD patients with cognitive impairment and age of onset, onset, motor symptoms related to the microelectrode-induced thalamus or globus pallidus damage on cognitive impairment is small, and many types of drug treatment are recognized in patients with PD Cognitive function impact, revealing the complex biochemical basis of cognitive changes in patients with PD.