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目的:考察消癥止痛方凝胶膏剂大鼠的透皮行为。方法:以延胡索乙素为指标,采用改良Franz扩散池法进行实验,HPLC测定样品的含量。结果:24 h累积经皮渗透率和速率分别为20.20%,0.744 1μg·cm-2·h-1。结论:消癥止痛方凝胶膏剂大鼠的经皮渗透行为符合零级动力学模型且离散度较小,经皮渗透行为较为理想。
Objective: To investigate the transdermal behavior of Xiaoyan Zhitong Fang Gel Adhesive. Methods: Tetrahydropalmatine was used as an index, and the experiment was carried out by the modified Franz diffusion cell method. The content of the sample was determined by HPLC. Results: The cumulative transdermal permeability and the rate of 24 h were 20.20% and 0.744 1 μg · cm-2 · h-1, respectively. Conclusion: The prescription of Xiaoyan Zhitong Fang Gel Adhesive has the best percutaneous dermal penetration in accordance with the zero-order kinetic model and the smaller dispersion and better percutaneous penetration.