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目的探讨保妇康栓联合LEEP锥切术治疗宫颈上皮内瘤变(CIN)伴高危型HPV感染的临床疗效。方法选取2015年1月至2016年1月收治的CIN合并HPV感染患者120例,按照随机数字法分为观察组和对照组,每组60例,对照组给予LEEP术进行治疗,观察组在对照组基础上于术后给予保妇康栓进行治疗,观察并比较两组患者阴道出血量及出血时间、阴道排液量及时间、宫颈创面愈合时间,并对术后3个月、6个月CIN治疗效果及HPV清除效果进行评价。结果观察组患者阴道出血量及出血时间、阴道排液量及时间、宫颈创面愈合时间均显著小于对照组(t=13.29、6.61、11.46、6.01、4.78,P<0.05),且盆腔疼痛发生率显著低于对照组(χ~2=11.64,P<0.05)。观察组患者术后3个月、术后6个月宫颈细胞学检查CIN治愈率为86.7%、96.7%,分别高于对照组的71.7%、81.7%(χ~2=4.09、6.99,P<0.05)。观察组患者术后3个月、6个月HPV转阴分别为36例、47例,转阴率分别为60.0%、78.3%,对照组术后3个月、6个月HPV转阴分别21例、28例,转阴率分别为35.0%、46.7%。观察组患者术后3个月、6个月的HPV转阴率均显著高于对照组(χ~2=5.64、12.84,P<0.05)。且观察组患者术后3个月、6个月单一基因型及混合基因型HPV转阴率也均显著高于对照组(χ~2≥3.96,P<0.05)。结论保妇康栓联合LEEP术可显著改善CIN伴高危型HPV感染患者术后临床症状,提高CIN治愈率和HPV转阴率。
Objective To investigate the clinical efficacy of Baofukang Suppository combined with LEEP conization in the treatment of cervical intraepithelial neoplasia (CIN) with high-risk HPV infection. Methods 120 patients with CIN complicated with HPV infection admitted from January 2015 to January 2016 were divided into observation group and control group according to random number method, 60 cases in each group. The control group was treated with LEEP, Group on the basis of postoperative Baofukang suppository treatment, observation and comparison of two groups of patients with vaginal bleeding and bleeding time, vaginal discharge and time, cervical wound healing time, and postoperative 3 months, 6 months CIN treatment and HPV clearance were evaluated. Results The vaginal bleeding volume, bleeding time, volume and time of vaginal discharge and the healing time of cervical wound in observation group were significantly lower than those in control group (t = 13.29,6.61,11.46,6.01,4.78, P <0.05), and the incidence of pelvic pain Significantly lower than the control group (χ ~ 2 = 11.64, P <0.05). In the observation group, the cure rates of cervical cytology CIN after 3 months and 6 months after operation were 86.7% and 96.7%, respectively, which were higher than 71.7% and 81.7% (χ ~ 2 = 4.09,6.99, P < 0.05). In the observation group, 36 cases (47 cases) were negative for HPV at 3 months and 6 months respectively, the negative conversion rates were 60.0% and 78.3% respectively. In the control group, HPV negative was 21 and 21 Cases, 28 cases, the negative conversion rates were 35.0%, 46.7%. In the observation group, the HPV negative conversion rates at 3 months and 6 months after operation were significantly higher than those in the control group (χ ~ 2 = 5.64,12.84, P <0.05). The HPV negative rates of single genotypes and mixed genotypes in observation group at 3 months and 6 months after operation were also significantly higher than those in control group (χ ~ 2≥3.96, P <0.05). Conclusion Baofukang suppository combined with LEEP can significantly improve the clinical symptoms of CIN patients with high-risk HPV infection and improve the cure rate of CIN and the rate of HPV negative conversion.