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目的 :了解地塞米松对创伤性休克时外周血一氧化氮和内皮素 -1的影响。方法 :复制兔创伤性休克模型 ,测定创伤前、后外周血内皮素 -1和一氧化氮浓度变化并观察地塞米松对内皮素 -1和一氧化氮浓度的影响。结果 :创伤性休克时 ,对照组内皮素 -1和一氧化氮浓度显著升高 (P <0 .0 1 ) ;治疗组内皮素 -1浓度升高更加显著 (P <0 .0 1 ) ,而一氧化氮浓度则明显降低 (P <0 .0 1 )。治疗组动物存活时间显著延长 (P <0 .0 1 )。结论 :内皮素 -1和一氧化氮参与了创伤性休克的病理损伤过程 ;地塞米松通过影响内皮素 -1和一氧化氮的浓度变化来发挥其对休克的治疗作用。
Objective: To investigate the effect of dexamethasone on nitric oxide and endothelin-1 in peripheral blood during traumatic shock. METHODS: Traumatic shock model was established in rabbits. The changes of endothelin-1 and nitric oxide in peripheral blood were measured before and after trauma and the effects of dexamethasone on the concentrations of endothelin-1 and nitric oxide were observed. Results: During traumatic shock, the concentrations of endothelin-1 and nitric oxide were significantly increased in the control group (P <0.01). The ET-1 concentration in the treatment group was significantly increased (P <0.01) While the concentration of nitric oxide decreased significantly (P <0.01). The survival time of treatment group was significantly longer (P <0.01). CONCLUSION: Endothelin-1 and nitric oxide are involved in the pathological process of traumatic shock. Dexamethasone exerts its therapeutic effect on shock by affecting the concentrations of endothelin-1 and nitric oxide.