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目的探讨分别含奥美拉唑和法莫替丁的三联疗法在消化性溃疡中的临床效果差异。方法 80例消化性溃疡患者,随机分为观察组和对照组,每组40例。观察组给予奥美拉唑、克拉霉素、呋喃唑酮治疗。对照组患者给予法莫替丁、阿莫西林、甲硝唑治疗。观察两组治疗效果、幽门螺杆菌根除情况。结果观察组治疗7 d症状改善的病例所占比例高于同期对照组,差异有统计学意义(P<0.05)。观察组幽门螺杆菌根除率高于对照组,差异有统计学意义(P<0.05)。观察组溃疡治疗总有效率(92.5%)高于对照组(72.5%),差异有统计学意义(P<0.05)。结论含奥美拉唑的三联疗法(奥美拉唑、克拉霉素、呋喃唑酮)治疗幽门螺杆菌阳性消化性溃疡的临床效果显著,值得借鉴。
Objective To investigate the clinical effects of triple therapy with omeprazole and famotidine respectively in peptic ulcer. Methods 80 patients with peptic ulcer were randomly divided into observation group and control group, 40 cases in each group. The observation group was treated with omeprazole, clarithromycin and furazolidone. Control group patients given famotidine, amoxicillin, metronidazole treatment. Observation of two groups of treatment, eradication of Helicobacter pylori. Results The proportion of cases with symptom improvement in observation group 7 days after treatment was higher than that in control group (P <0.05). The eradication rate of Helicobacter pylori in the observation group was higher than that in the control group, with significant difference (P <0.05). The total effective rate of treatment group (92.5%) was higher than that of control group (72.5%), the difference was statistically significant (P <0.05). Conclusion The triple effect of omeprazole (omeprazole, clarithromycin, furazolidone) in the treatment of Helicobacter pylori-positive peptic ulcer clinical effect is significant, it is worth learning from.