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氯喹视网膜病变常见的视野缺损有傍中心或中心周围的暗点。。本文报告一例45岁女性慢性类风湿性关节炎,服氯喹每天250毫克共10年。眼底视乳头及黄斑部正常,有双颞侧视野缺损,曾怀疑有垂体肿瘤,神经系统检查,头颅X光蝶鞍断层相片,气脑造影,及颈动脉造影均正常。隔5—8周复查,视野显示进行性视野丧失。视交叉部手术探查未发现异常。裂隙灯检查右角膜有细小的上皮变化,符合氯喹角膜病变。眼底:视乳头轻度苍白,视网膜小动脉狭窄,双黄斑部有色素病损,病损外围有发亮的晕呈特征性的“牛眼环”(bull’s eye)状外观。周边部视网膜
Chloroquine retinopathy common visual field defects near the center or center of the dark spots. . This article reports a 45-year-old woman with chronic rheumatoid arthritis who takes chloroquine 250 mg daily for 10 years. Posterior ocular fundus and macular normal, there are bilateral temporal visual field defects, had suspected pituitary tumors, neurological examination, skull X-ray sessile photographs, angiography, and carotid angiography were normal. 5-8 weeks after the review, the visual field showed progressive loss of vision. No abnormalities were found in the optic chiasm. Slit lamp examination of the right cornea with small epithelial changes, consistent with chloroquine corneal lesions. Fundus: The optic disc was slightly pale, the retinal arterioles narrowed, the pigmented lesions in the double macular area showed a characteristic “bull’s eye” -like appearance on the periphery of the lesion. Peripheral retinal