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目的:探讨氨氯地平联合氯沙坦治疗老年高血压合并早期肾损害(HypertensionwithRenalFailure,HRF)临床疗效。方法:收集近期我院收治的52例老年HRF患者。对照分析治疗前和治疗5周后血压、尿微量白蛋白情况。结果:联合药物治疗的52例患者,收缩压改善率17.5%,舒张压改善率21.9%,治疗后收缩压、舒张压分别降至129.5mmHg、74.6mmHg,而mALB排泄率降低至72.6±26.5μg/min,且未增加并发症。结论:氨氯地平与氯沙坦联合治疗老年HRF疗效确切,安全可靠。
Objective: To investigate the clinical efficacy of amlodipine plus losartan in the treatment of elderly hypertensive patients with early renal damage (HRF). Methods: Fifty-two elderly HRF patients were collected in our hospital recently. Control analysis of blood pressure and urine albumin before treatment and after 5 weeks of treatment. Results: In the 52 patients treated with combination therapy, the systolic pressure improvement rate was 17.5% and the diastolic blood pressure improvement rate was 21.9%. After treatment, the systolic and diastolic blood pressure dropped to 129.5mmHg and 74.6mmHg respectively, while the mALB excretion rate decreased to 72.6 ± 26.5μg / min, and did not increase the complications. Conclusion: Amlodipine combined with losartan in the treatment of elderly HRF is effective, safe and reliable.