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目的:观察运脾化湿方联合西药治疗高血压病伴头晕患者的疗效。方法:选取102例高血压病伴头晕患者为研究对象,采用随机数字表法分为观察组和对照组各51例,对照组给予常规抗压药治疗,观察组在此基础上加服运脾化湿方,2组均治疗2月,比较2组治疗前后血管活性肠肽(VIP)、白细胞介素-2(IL-2)、C-反应蛋白(CRP)、收缩压(SBP)及舒张压(DBP)的变化,应用眩晕评定量表(DARS)分析患者的头晕状况,同时采用焦虑自评量表(SAS)、抑郁自评量表(SDS)、卡氏功能状态评分(KPS)分析患者的情绪状态及生活质量,并记录不良反应发生情况。结果:治疗后,2组VIP、CRP、IL-2、DARS评分、SBP、DBP、KPS、SAS评分及SDS评分均较治疗前改善(P<0.05);观察组VIP含量、KPS均高于对照组(P<0.05),血清CRP、IL-2、DARS评分、SBP、DBP、SAS评分及SDS评分均低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:采用运脾化湿方联合西药治疗高血压病伴头晕患者疗效较好,可能通过促进VIP分泌、抑制炎症因子等机制控制患者病情,提高生活质量。
Objective: To observe the effect of Yunpi Huashi Decoction combined with western medicine on patients with hypertension and dizziness. Methods: A total of 102 hypertensive patients with dizziness were enrolled in this study. Fifty-one patients in the observation group and the control group were randomly divided into observation group and control group. The control group was treated with conventional antihypertensive drugs. On the basis of this, Huashi Decoction and two groups were treated for two months. The levels of vasoactive intestinal peptide (VIP), interleukin-2 (IL-2), C-reactive protein (CRP), systolic pressure (SBP) (DBS), dizziness status was analyzed by DARS, SAS, KDS and KPS were used to analyze the changes of DBP. Patient’s emotional status and quality of life, and record the occurrence of adverse reactions. Results: After treatment, the VIP, CRP, IL-2, DARS score, SBP, DBP, KPS, SAS score and SDS score of two groups were all improved than those before treatment (P < (P <0.05). Serum CRP, IL-2, DARS score, SBP, DBP, SAS score and SDS score were lower than the control group (P <0.05). The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). Conclusion: Yunpi Huashi Decoction combined with western medicine is effective in treating patients with hypertension and dizziness. It may control the patient’s condition and improve the quality of life by promoting VIP secretion and inhibiting inflammatory cytokines.